Dibidang kesehatan, sarana dan prasarana kesehatan tersebar hampir diseluruh kecamatan. Terdapat 2 buah Rumah Sakit yang terletak di Kecamatan Kota Soe dan 770 posyandu masing-masing dikecamatan dimana terbesar terdapat di kecamatan amanatun selatan sebanyak 39 buah.
Jumlah Sarana Kesehatan di Kab. TTS Tahun 2014-2018
| No. | Sarana Kesehatan | Tahun | ||||
| 2014 | 2015 | 2016 | 2017 | 2018 | ||
| 1 | Rumah Sakit | 1 | 2 | 3 | 3 | 3 |
| 2 | Rumah Bersalin | – | 5 | 5 | 5 | 5 |
| 3 | Rumah Sakit Khusus | 1 | – | – | – | – |
| 4 | Klinik/Balai Kesehatan | 3 | 4 | 11 | 10 | 4 |
| 5 | Puskesmas | 30 | 35 | 35 | 36 | 36 |
| 6 | Puskesmas Pembantu | 63 | 58 | 63 | 63 | 56 |
| 7 | Puskesmas Rawat Inap | 8 | 9 | 8 | 8 | 9 |
| 8 | Puskesmas Non Rawat Inap | 22 | 26 | 27 | 27 | 27 |
| 9 | Ruang Bersalin | 5 | 5 | 5 | 5 | 5 |
| 10 | Polindes | – | – | 70 | – | – |
| 11 | Posyandu | 766 | 770 | 788 | 788 | 824 |
| 12 | Puskesmas Keliling | 30 | 35 | 35 | 35 | 35 |
| 13 | Toko Obat | 1 | 1 | 1 | 1 | 1 |
| 14 | Apotek | 2 | 3 | 6 | 6 | 8 |
Jumlah Sarana Kesehatan Menurut Kecamatan, 2015
| Kecamatan | Rumah Sakit | Rumah Bersalin | Puskesmas | Posyandu | Klinik/ Balai Kesehatan | Polindes |
| Mollo Utara | – | – | 1 | 47 | – | 3 |
| Fatumnasi | – | – | 1 | 12 | – | 0 |
| Tobu | – | – | 1 | 15 | – | 2 |
| Nunbena | – | – | 1 | 12 | – | 1 |
| Mollo Selatan | – | – | 1 | 19 | – | 0 |
| Polen | – | – | 2 | 32 | – | 7 |
| Mollo Barat | – | – | 1 | 11 | – | 1 |
| Mollo Tengah | – | – | 1 | 15 | – | 4 |
| Kota SoE | 3 | 5 | 1 | 38 | 4 | 5 |
| Amanuban Barat | – | – | 1 | 22 | – | 3 |
| Batu Putih | – | – | 1 | 21 | – | 0 |
| Kuatnana | – | – | 1 | 21 | – | 5 |
| Amanuban Selatan | – | – | 1 | 39 | – | 1 |
| Noebeba | – | – | 2 | 24 | – | 0 |
| Kuanfatu | – | – | 1 | 31 | – | 3 |
| Kualin | – | – | 1 | 30 | – | 1 |
| \Amanuban Tengah | – | – | 1 | 28 | – | 9 |
| Kolbano | – | – | 2 | 34 | – | 4 |
| Oenino | – | – | 1 | 21 | – | 2 |
| Amanuban Timur | – | – | 1 | 35 | – | 3 |
| Fautmolo | – | – | 1 | 12 | – | 1 |
| Fatukopa | – | – | 1 | 8 | – | 1 |
| KiE | – | – | 1 | 36 | – | 4 |
| Kot’Olin | – | – | 1 | 29 | – | 1 |
| Amanatun Selatan | – | – | 1 | 43 | – | 5 |
| Boking | – | – | 1 | 22 | – | 0 |
| Nunkolo | – | – | 1 | 32 | – | 0 |
| Noebana | – | – | 1 | 12 | – | 1 |
| Santian | – | – | 1 | 13 | – | 0 |
| Amanatun Utara | – | – | 1 | 27 | – | 0 |
| Toianas | – | – | 1 | 21 | – | 3 |
| Kokbaun | – | – | 1 | 8 | – | 0 |
| Timor Tengah Selatan | 3 | 5 | 35 | 770 | 4 | 70 |